Acute Decompensated Heart Failure (ADHF) is a life-threatening acute presentation of heart failure, and is the cause of up to 2 million US emergency hospital admissions annually. Patients present with congestion & fluid retention, shortness of breath and lower limb swelling. For many patients, emergency hospital admission is required. Poor treatment outcomes are common with 60% of hospitalized patients discharged with persistent congestion, leading to short-term re-hospitalization, poor quality of life, and high mortality.